The airport has three runways, the primary one measuring 4,900 metres (the longest civilian runway in the Southern Hemisphere and one of the few able to land a space shuttle). Both South African Airways and the South African Air Force use the airport to train pilots in the handling of large aircraft such as 747s, 707s and the South African presidential jet.
The airport also does a brisk business in cargo, sending anything from livestock to cars and mining equipment to Europe, the Middle East and the rest of Africa. Not to mention grapes, about one million tons of which are flown from Upington every year.